The fault in our genes? Genetic factors have an effect on wherever fat is keep in bodies

LONDON: Researchers have found that whether or not you store your fat around the trunk or in different elements of your body is very influenced by genetic factors. The study, revealed within the journal Nature Communications, conjointly according to that this result is gift preponderantly in girls and to a way lower extent in men.

“We understand Women and men tend to store fat otherwise – women have the power to additional simply store fat on the hips and legs, whereas men tend to accumulate fat around the abdomen to the next extent,” aforesaid lead author Mathias Rask-Andersen from urban center University in Sweden.

“This has been attributed to the results of sex hormones like steroid hormone. however the molecular mechanisms that manage this development are fairly unknown,” Rask-Andersen additional.

For the study, the researchers measured however fat was distributed in nearly 360,000 voluntary participants. The participants gave blood samples for genotyping and therefore the distribution of fat tissue was calculable mistreatment resistivity measurements, i.e. measurements of resistance once AN electrical current is fed through the body.

In the study, uncountable genetic variants across the ordination were tested for association with distribution of fat to the arms, legs or trunk, and therefore the analysis team has known nearly 100 genes that have an effect on the distribution of fatty tissue to the various compartments of the figure.

The findings recommend that remodeling of the extracellular matrix is one among the mechanisms that generate variations in body fat distribution, the researchers aforesaid.

Fat keep within the trunk has antecedently been related to exaggerated malady risk. Men have a bigger quantity of abdominal fat than girls and this might justify the exaggerated prevalence of disorder discovered in males.

Epidemiological studies have even shown that the power to store fat around the hips and legs offers girls some protection against disorder.

The results of this study could thus cause the event of the latest interventions to cut back the danger of disorder.

“The biological systems we have a tendency to highlight in our study have the potential to be used as points-of-intervention for a brand spanking new medicine that is geared toward up the distribution of body fat and thereby reducing the danger of malady,” Mathias Rask-Andersen noted.